Access-Controlled Oxidation: Understanding the Role of Structure in Protein Damage
Loughborough UniversityLoughborough, United Kingdom
Course overview
Protein oxidation is a major marker of protein damage in aging and disease processes, and can occur through a number of routes. One poorly understood contributing element is how protein structure, including local structure, controls the outcomes of oxidation events in the body. This project seeks to establish the role of structure so that health impacts can be better predicted.
As part of our team, you will look at the influence of protein structure in changing the accessibility and reactivity of reactive species, particularly radicals with disease-linked proteins. You will use and develop state-of-the-art computational methods, to complement experiments carried out by our collaborators at Copenhagen University in Denmark. This will enable us to more fully understand the radical reactions and their outcomes, alongside their biological impact.
Where required, training in specific computational methods (molecular dynamics, quantum mechanics, machine learning) will be provided. You will also have a range of opportunities to gain valuable transferrable skills (including through our doctoral college), network with international and industry partners, and be well-set up for a role in either industry, data science or academia at the end of the programme. 94% of Loughborough’s research impact is rated world-leading or internationally excellent.
REF 2021
Key highlights
- Investigates how protein structure controls oxidation and radical reactions
- Develops state-of-the-art computational methods alongside experimental collaborators
- Collaboration with Copenhagen University researchers in Denmark
- Training provided in molecular dynamics, quantum mechanics and machine learning
- Transferable skills development through the doctoral college
- Networking opportunities with international and industry partners
Entry requirements
- Degree: 2:1 — or above
Scholarships
Alumni Bursary
10% of tuition fees which will be credited to the student’s tuition fee account.
Up to 10% of feesAlumni Discount
UK students: £1,500 tuition fee discount for one academic year. International students: £3,000 tuition fee discount for one academic year.
Care Leaver's Scholarship
Excellence Scholarships
UK students: £3,000 off tuition fees; International students: £6,000 off tuition fees which will be credited to the student’s tuition fee account.
International Sports Student Postgraduate Bursary
Our International Sports Student Postgraduate Bursary offers a £12,000 tuition fee discount (set against the tuition fees of your chosen postgraduate taught programme ONLY).
Up to £12,000London 10th Anniversary Award
£5,000 off tuition fees.
Up to £5,000Loughborough Business School Scholarship
£1,500 (UK students) and £3,000 (international students) off tuition fees which will be credited to the student’s tuition fee account.
MBA Progress with Purpose Scholarship
50% of tuition fees which will be credited to the student’s tuition fee account.
Up to 50% of feesQatari Ghanim Al-Muftah Excellence Scholarship
Careers this course leads to
- Postdoctoral research associate
- Computational chemist
- Data scientist
- Computational biologist
- University lecturer
- Industrial research scientist
Cost of study
UK/Home: £5,238 | International: £29,500
Admission
Applications are made through AHZ at no cost. Share your transcripts, English test scores and personal statement, and your AHZ Counsellor will review your profile, submit your application to Loughborough University, and guide you through interview, offer, CAS and visa — right up to enrolment.
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