Novel functions of the epigenetic cancer driver KMT2D
Aston UniversityBirmingham, United Kingdom
Course overview
KMT2D, previously also known as MLL2 in humans, is a histone 3 lysine 4 (H3K4) methyltransferase. It has attracted attention as it is within the top 10 most mutated genes in cancer genomes, as well as the main reason behind the congenital disorder Kabuki syndrome. Importantly, in contrast to other cancer genes, the functions of KMT2D have not been clearly established yet.
It is believed that KMT2D works through methylating H3K4 in chromatin, a mark of active transcription, and facilitating enhancer mediated transcriptional activation.
Key highlights
- Research into KMT2D, among the ten most mutated cancer genes
- Investigates poorly understood functions of an epigenetic cancer driver
- Explores H3K4 methylation and enhancer-mediated transcriptional activation
- Links to Kabuki syndrome, a congenital disorder caused by KMT2D
Entry requirements
- IELTS: 6.5 — 6.5 IELTS 6.5 overall (component minima vary by programme; see university English-language requirements)
Careers this course leads to
- Postdoctoral research scientist
- Cancer research scientist
- Epigenetics researcher
- University lecturer in biosciences
- Biotechnology research scientist
- Pharmaceutical drug discovery scientist
Admission
Applications are made through AHZ at no cost. Share your transcripts, English test scores and personal statement, and your AHZ Counsellor will review your profile, submit your application to Aston University, and guide you through interview, offer, CAS and visa — right up to enrolment.
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