Loughborough University

Synthesis of Fluorinated Heterocycles

Loughborough UniversityLoughborough, United Kingdom

Course overview

Compounds based on pyridones, cinnolines, or quinoxalines will be synthesised using nucleophilic aromatic substitution (SNAr) of fluoroarenes to allow rapid construction of small molecules of interest as drug candidates for antibiotics, anti-cancer agents, or treatments against Neglected Tropical Diseases. The SNAr reaction represents a versatile method to prepare compounds suitable for biological screening in only two or three steps. The presence of fluorine in the compounds can improve their drug properties and also allows further derivatisation to modify the structures in response to screening results.

New compounds will be analysed by ¹H, ¹³C, and ¹⁹F NMR spectroscopy, mass spectrometry, and X-ray diffraction to confirm structural identity and purity. The project will provide thorough training in synthetic, mechanistic, and medicinal chemistry, and contribute new methods for drug development. 94% of Loughborough’s research impact is rated world-leading or internationally excellent.

REF 2021

Key highlights

  • Synthesise pyridone, cinnoline and quinoxaline compounds via SNAr of fluoroarenes
  • Targets antibiotics, anti-cancer agents and Neglected Tropical Disease treatments
  • Prepare biologically screenable compounds in only two or three steps
  • Hands-on analysis using NMR spectroscopy, mass spectrometry and X-ray diffraction
  • Thorough training in synthetic, mechanistic and medicinal chemistry
  • Contribute new synthetic methods for drug development

Entry requirements

  • Degree: 2:1 — 2:1

Scholarships

  • Alumni Bursary

    10% of tuition fees which will be credited to the student’s tuition fee account.

    Up to 10% of fees
  • Alumni Discount

    UK students: £1,500 tuition fee discount for one academic year. International students: £3,000 tuition fee discount for one academic year.

  • Care Leaver's Scholarship

  • Excellence Scholarships

    UK students: £3,000 off tuition fees; International students: £6,000 off tuition fees which will be credited to the student’s tuition fee account.

  • International Sports Student Postgraduate Bursary

    Our International Sports Student Postgraduate Bursary offers a £12,000 tuition fee discount (set against the tuition fees of your chosen postgraduate taught programme ONLY).

    Up to £12,000
  • London 10th Anniversary Award

    £5,000 off tuition fees.

    Up to £5,000
  • Loughborough Business School Scholarship

    £1,500 (UK students) and £3,000 (international students) off tuition fees which will be credited to the student’s tuition fee account.

  • MBA Progress with Purpose Scholarship

    50% of tuition fees which will be credited to the student’s tuition fee account.

    Up to 50% of fees
  • Qatari Ghanim Al-Muftah Excellence Scholarship

Careers this course leads to

  • Medicinal chemist
  • Synthetic organic chemist
  • Pharmaceutical research scientist
  • Postdoctoral research associate
  • Analytical chemist
  • Process development chemist

Cost of study

UK/Home: £5,238 | International: £29,500

Admission

Applications are made through AHZ at no cost. Share your transcripts, English test scores and personal statement, and your AHZ Counsellor will review your profile, submit your application to Loughborough University, and guide you through interview, offer, CAS and visa — right up to enrolment.

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