Understanding RNAi application for the control of cabbage stem flea beetle (WELLSR_JU26CRODAEPSRC)

Insect pests represent a global threat to agricultural production, causing losses of up to 40%/annum. Historically, pesticides have limited crop loss, however, adverse environmental effects and impacts on non-pest species, coupled with increased resistance to chemical pesticides, have identified the need for targeted, sustainable solutions. The control of insect pests via RNAi offers an exciting new approach.

The cabbage stem flea beetle (CSFB; Psylliodes chrysocephala) is an insect pest of Brassica crops, particularly oilseed rape (OSR; Brassica napus). The EU-wide ban on neonicotinoid usage (2018), coupled with pyrethroid resistance, has contributed to a >60% reduction in UK OSR cropping area since 2013. Specific RNA based products have been shown to cause up to 76% beetle mortality upon feeding (Ceddan et al., 2022, 2024, Guo et al., 2023).

However, loss of efficacy can occur from variation in RNA efficiency, adjuvant formulation, application methodology and environment. Understanding the factors related to effective silencing is key for the development of novel controls. In collaboration with CRODA, JIC have developed RNA based product testing systems.

Using our captive CSFB colony and CRODAs application development knowledge, the student will progress the understanding of the mechanism and efficacy of RNA based formulations to support the development of targeted pest control. They will join a collaborative research team, in the Wells and Morris labs, experienced in worki