Luminescent Molecular Probes to Detect Phosphate in UK Waterways

A major unsolved challenge for environmental agencies is to monitor inorganic phosphate in water, to predict the breakout of harmful algae blooms that lead to aquatic “dead zones”. To solve this challenge, in this PhD project we will synthesise molecular probes that bind selectively to phosphate anions and generate a sensitive luminescent signal that enables precise measurement of phosphate in water. In collaboration with the Loughborough EcoSENSE team, we will encapsulate our luminescent probes into hydrogel materials using our patented technology, thereby delivering new tools for the measurement of aqueous phosphate levels.

This project will provide a vital step towards the accurate mapping and prediction of harmful algae blooms, alerting environmental and health agencies to take appropriate action to maintain and improve water quality. Full Project Detail High levels of inorganic phosphate released into waterways through sewage, fertiliser, and pesticides are a primary cause of the spread of environmentally detrimental algae. The cost of responding to water-based phosphate pollution in the UK alone is estimated at £170 million per year.

Crucially, there are no existing sensors or devices capable of detecting phosphate that have been miniaturised for point-of-need testing and mapping of large waterways (e.g. rivers and lakes). We have established the design principles to create luminescent probes that exhibit high binding selectivity for target biological phosphate anions ( Chem. Sci., 2022, 13, 3386).

We will build on this knowledge to develop probes with enhanced sensitivity for inorganic phosphate and minimal interference compared with existing sensing methods. We will encapsulate these luminescent probes into hydrogel materials using our patented technology, thereby delivering a new method for the measurement of aqueous phosphate levels. The student will gain excellent training in a range of techniques including organic synthesis, study of supramolecular host–guest interactions, and luminescence assay development.

They will be supported by other researchers within the Butler Group and will be very well trained for roles in industry through collaboration with industrial partners. Environmental and biotechnology companies increasingly require scientists with combined synthetic and bioana